121. Freigang, S.; Zadorozhny, V.; McKinney, M.; Krebs, P.; Schrantz, N.; Masuda, K.; Liu, Y.; Savage, P. B.; Bendelac, A.; Cravatt, B. F.; Teyton, L. J. Exp. Med. submitted. Fatty acid amide hydrolyase shapes NKT cell responses by regulating the serum transport of lipid antigen.

 

120. Roohi, S.; Amir, N. ;Savage, P. B. Salman, A. M.; Saleem, A. J. Nuclear. Med. submitted.  Biological evaluation of 99mTc-CSA-13 in animal models of infections and inflammation.

 

119. Li, B.; Sagiv, Y.; Liu, Y.; Freigang, S.; Teyton, L.; Porcelli, S. A.; Savage, P. B.; Bendelac, A. Immunity submitted. Lipid structure differentially regulates glycosphingolipid uptake and CD1d-mediated presentation. 

 

118. Koh, Y. I.; Kim, H. Y.; Meyer, E. H.; Pichavant, M.; Akabri, O.; Yasumi, T.; Savage, P. B.; DeKruyff, R. H.; Umetsu, D. T. J. Immunol. 2008, 181, 4560-4569. Activation of nonclassical CD1d restricted natural killer T cells induces airway hyperreactivity in β2-microglobulin deficient mice.

 

117. Lai, X.-Z.; Feng, Y.; Pollard, J.; Chin, J. N.; Rybak, M. J.; Bucki, R.; Epand, R. F.; Epand, R. M.; Savage, P. B. Acc. Chem. Res. 2008, 41, 1233-1240.  Ceragenins: cholic acid-based mimics of antimicrobial peptides.

 

116. Roohi, S.; Amir, N.; Ahmed, M.; Savage, P. B.; Saluhiddin, S. M.; Jehangir, M. J. Radioanal. Nuclear Chem. 2008, in press. Synthesis, quality control and biological evaluation of 99mTc labeled CSA-13.

 

115. Farruggia, G.; Iotti, S.; Prodi, L.; Zaccheroni, N.; Montalti, M.; Savage, P. B.; Andreani, G.; Trapani, V.; Wolf, F. I. J. Fluorescence 2008, in press.

 

114. Epand, R. M.; Epand, R. F.; Savage, P. B. Drug News Perspect. 2008, 21, 307-311. Ceragenins (cationic steroid compounds), a novel class of antimicrobial agents.

 

113. Saha, S.; Savage, P. B.; Bal M. J. Appl. Microbiol. 2008, 105, 822-828.  Enhancement of the efficacy of erythromycin in multiple antibiotic-resistant gram-negative bacterial pathogens.

 

112. Isogai, E.; Isogai, H.; Takahashi, K.; Okumura, K.; Savage, P. B. Oral Microbiol. Immunol. 2008, in press. Ceragenin CSA13 exhibits antimicrobial activity against cariogenic and periodontopathic bacteria.

 

111. Pichavant, M.; Goya, S.; Meyer, E. H.; Johnston, R. A.; Kim, H. Y.; Matagkasombut, P.; Zhu, M.; Iwakura, Y.; Savage, P. B.; DeKruyff, R. H.; Shore, S. A.; Umetsu, D. T. J. Exp. Med. 2008, 205, 385-393. Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17.

 

110. Mattner, J.; Savage, P. B.; Leung, P.; Oertelt, S. S.; Wang, V.; Trivedi, O.; Scanlon, S. T.; Teyton, L.; Hart, J.; Ridgway, W. M.; Wicker, L. S.; Gershwin, E. M.; Bendelac, A. Cell Host Microbe 2008, 3, 304-315. Liver autoimmunity triggered by microbial activation of NKT cells.

 

109. Matangkasombut, P.; Pichavant, M.; Yasumi, T.; Hendricks, C.; Savage, P. B.; DeKruyff, R. H.; Umetsu, D. T. J. Allergy Clin. Immunol. 2008, 121, 1287-1289.  Direct activation of natural killer T cells induces airway hyprreactivity in nonhuman primates.

 

108. Fuangswasdi, S.; Kaveevivitchai, N.; Tuntulani, T.; Savage, P. B. J. Solution Chem. 2008, 37, 45-58. Complexing properties of phenolic diazacrown ethers with transition and heavy metal ions.

 

107. Zajonc, D.; Savage, P. B.; Bendelac, A.; Wilson, I.; Teyton, L. J. Mol. Biol. 2008, 377, 1104-1116. Crystal structures of mouse CD1d-iGb3 complex and its cognate Vα14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids.

 

106. Bucki, R.; Namiot, D. B.; Namiot, Z.; Savage, P. B.; Janmey, P. A. J. Antimicrob. Chemother. 2008, 62, 329-335. Salivary mucins inhibit antibacterial activity of cathelicidin-derived LL-37 peptide but not the cationic steroid CSA-13.

 

105. Savage, P. B.; Nielsen, J.; Lai, X.-Z.; Feng, Y.; Li, Y.; Nelson, G.; Linford, M. R.; Genberg, C. Antibacterial activities of thin films containing ceragenins. In Camesano, T.A. and Mello, C. (Eds.). Microbial Surfaces: Structure, Interactions and Reactivity.  ACS Symposium Series 984, Washington, D.C.: American Chemical Society, 2008, 65-78.

 

104. Liu, Y.; Deng, S.; Bai, L.; Freigang, S.; Mattner, J.; Teyton, L.; Bendelac, A.; Savage, P. B. Bioorg. Med. Chem. Lett. 2008, 18, 3052-3055. Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties.

 

103. Chin, J. N.; Jones, R. N.; Sader, H. S.; Savage, P. B.; Rybak, M. J. J. Antimicrob. Chemother. 2008, 61, 365-370. Potential synergy activity of the novel ceragenin, CSA-13 against clinical isolates of Pseudomonas aeruginosa, including multi-drug resistant P. aeruginosa.

 

102. Posner, R. G.; Geng, D.; Haymore, S.; Bogert, J.; Pecht, I.; Licht, A.; Savage, P. B. Org. Lett. 2007, 9, 3551-3554. Trivalent antigens for degranulation of mast cells.

 

101. Long, X.; Deng, S.; Zang, Z.; Mattner, J.; Zhou, D.; McNary, N.; Goff, R. D.; Teyton, L.; Bendelac, A.; Savage, P. B. Nature Chem. Biol. 2007, 3, 559-564. Synthesis and evaluation of stimulatory properties of Sphingomonadacea glycolipids.

 

100. Epand, R. F.; Savage, P. B.; Epand, R. M. Biochim. Biophys. Acta 2007, 1768, 2500-2509.  Bacterial lipid composition and the antimicrobial efficacy of cationic steroid compounds (ceragenins).

 

99. Sagiv, Y.; Bai, L.; Wei, D. G.; Agami, R.; Savage, P. B.; Teyton, L.; Bendelac, A. J. Exp. Med. 2007, 204, 921-928. A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d.

 

98. Michel, M.-L.; Keller, A. C.; Paget, C.; Fujio, M.; Trottein, F.; Savage, P. B.; Wong, C. H.; Schneider, E.; Dy, M.; Liete de Moraes, M. J. Exp. Med. 2007, 204, 995-1001.  Identification of a new IL-17-producing iNKT cell subset involved in airway neutrophilia.

 

97. Meyer, E. H.; Wurbel, M. A.; Staton, T. L.; Pichavant, M.; Savage, P. B.; Kan, M. J.; DeKruyff, R.; Butcher, E. C.; Campbell, J. J.; Umetsu, D. Immunity 2007, 179, 4661-4671. iNKT cells require CCR4 to localize to the airways and to induce airway-hyperreactivity.

 

96. Chin, J. N.; Rybak, M. J.; Cheung, C. M.; Savage, P. B. Antimicrob. Agents Chemother. 2007, 51, 1268-1273. Antimicrobial activity of novel ceragenins against clinical isolates of resistant Staphylococcus aureus.

 

95. Bendelac, A.; Savage, P. B.; Teyton, L. Annual Rev. Immunol. 2007, 25, 297-336. Biology of NKT cells.

 

94. Schrantz, N.; Sagiv, Y.; Liu, Y.; Savage, P. B.; Bendelac, Teyton, L. J. Exp. Med. 2007, 204, 841-852. The Niemann-Pick Type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells.

 

93. Bucki, R.; Sostarecz, A. G.; Byfield, F. J.; Savage, P. B.; Janmey, P. A. J. Antimicrob. Chemother. 2007, 60, 535-545. Resistance of the antibacterial agent ceragenin CSA-13 to inactivation by DNA of F-actin, and its activity in cystic fibrosis sputum. 

 

92. Savage, P. B.; Bendelac, A.; Teyton, L. Chem. Soc. Rev. 2006, 35, 771-779. Glycolipids for natural killer T cells.

 

91. Sagiv, Y.; Hudspeth, K.; Mattner, J.; Schrantz, N.; Stern, R. K.; Zhou, D.; Savage, P. B.; Teyton, L.; Bendelac, A. J. Immunol. 2006, 177, 26-30. Cutting edge: Impaired glycosphingolipids trafficking and NKT cell development in mice lacking Niemann-Pick Type C1 protein.

 

90. Campos-Martín, Y.; Colmenares, M.; Gozalbo-López, B.; López-Núñez, M.; Savage, P. B.; Martínez-Naves, E. J. Immunol. 2006, 176, 6172-6179. Immature human dendritic cells infected with Lieshmania infantum are resistant to NK-mediated cytolysis but are efficiently recognized by NKT cells. 

 

89. Wei, D. G.; Curran, S. A.; Savage, P. B.; Teyton, L.; Bendelac, A. J. Exp. Med. 2006, 203, 1197-1207. Mechanisms imposing the V-beta bias of V-alpha-14 NKT cells and consequences for microbial glycolipid recognition.

 

88. Meyer, E. H.; Goya, S.; Akbari, Ol.; Berry, G. J.; Savage, P. B.; Kronenberg, M.; Nakayama, T.; DeKruyff, R. H.; Umetsu, D. T. Proc. Natl Acad. Sci. 2006, 103, 2782-2787. Glycolipid mediated activation of iNKT cells is sufficient to induce airway hyperreactivity indpendent of conventional CD4+ T cells.

 

87. Liu, Y.; Goff, R. D.; Zhou, D.; Mattner, J.; Sullivan, B. A.; Khurana, A.; Cantu, C.; Altman, J. D.; Teyton, L.; Bendelac, A.; Savage, P. B. J. Immun. Methods 2006, 312, 34-39. A modified α-galactosyl ceramide for staining and stimulating natural killer T cells.

 

86. Farruggia, G.; Iotti, S.; Prodi, L.; Montalti, M.; Zaccheroni, N.; Savage, P. B.; Trapani, V.; Sale, P.; Wolf, F. I. J. Am. Chem. Soc. 2006, 127, 344-350. 8-Hydroxyquinoline derivatives as fluorescent sensors for magnesium in living cells.

 

85. Kichler, A.; Leborgne, C.; Savage, P. B.; Danos, O. J. Controlled Release 2005, 107, 174-182.  Cationic steroid antibiotics demonstrate DNA delivery properties.

 

84. Zajonc, D. M.; Cantu, C. III; Mattner, J.; Zhou, D.; Savage, P. B.; Bendelac, A.; Wilson, I. A.; Teyton, L. Nature Immunol. 2005, 6, 810-818. Structure and function of a potent α-galactosylceramide agonist for the semi-invariant NKT cell receptor.

 

83. Mattner, J.; DeBord, K. L.; Goff, R. D.; Cantu, C.; Zhou, D.; Saint-Mezard, P.; Wang, V.; Gao, Y.; Yin, N.; Hoebe, K.; Schneewind, O.; Ismail, N.; Walker, D.; Buetler, B.; Teyton, L.; Savage, P. B.; Bendelac, A. Nature 2005, 434, 525-528.  Both exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections.

 

82. Bronson, R. T.; Michaelis, D. J.; Lamb, R. D.; Husseini, G. A.; Farnsworth, P. B.; Linford, M. A.; Izatt, R. M; Bradshaw, J. S.; Savage, P. B. Org. Lett. 2005, 7, 1105-1108. Efficient immobilization of a cadmium chemosensor in a thin film: generation of a cadmium sensor prototype.

 

81. Lua, Y. Y.; Fillmore, W. J. J.; Yang, L.; Lee, M. V.; Savage, P. B.; Asplund, M. C.; Linford, M. R. Langmuir 2005, 21, 2093-2097. First reaction of a bare silicon surface with acid chlorides and a one-step preparation of a acid chloride terminated monolayers on scribed silicon.

 

80. Lua, Y. Y.; Yang, L.; Pew, C. A.; Zhang, F.; Fillmore, W. J. J.; Bronson, R. T.; Sathyapalan, A.; Savage, P. B.; Whittaker, J. D.; Davis, R. C.; Linford, M. R. J. Am. Soc. Mass Spec. 2005, 16, 1575-1582. Polyelectrolytes as new matrices for secondary ion mass spectrometry.

 

79. Zhou, D.; Mattner, J.; Cantu, C.; Schrantz, N.; Yin, N.; Gao, Y.; Sagiv, Y.; Hudspeth, K.; Wu, Y.; Yamashita, T.; Teneberg, S.; Wang, D.; Proia, R.; Levery, S. B.; Savage, P. B.; Teyton, L.; Bendelac, A. Science 2004, 306, 1786-1789. Lysomal glycosphingolipid recognition by NKT cells.

 

78. Ding, B.; Taotafa, U.; Orsak, T.; Chadwell, M. Org. Lett. 2004, 6, 3433-3436. Synthesis and characterization of peptide-cationic steroid antibiotic conjugates.

 

77. Savage, P. B.; Li, C. “Steroid Derived Antibiotics,” US patent # 6,767,904, July 27, 2004.

 

76. Ding, B.; Yin, N.; Liu, Y.; Cardenas-Garcia, J.; Evanson, R.; Orsak, R.; Fan, M.; Turin, G.; Savage, P. B. J. Am. Chem. Soc. 2004, 126, 13642-13648. Origins of cell selectivity of cationic steroid antibiotics.

 

75. Goff, R. D.; Gao, Y.; Mattner, J.; Zhou, D.; Yin, N.; Cantu, C. III; Teyton, L.; Bendelac, A.; Savage, P. B. J. Am. Chem. Soc. 2004, 126, 13602-13603. Effects of lipid chain lengths in α-galactosylceramides on cytokine release by natural killer T cells.

 

74. Bronson, R. T.; Montalti, M.; Prodi, L.; Zaccheroni, N.; Lamb, R. D.; Dalley, N. K.; Izatt, R. M.; Bradshaw, J. S.; Savage, P. B. Tetrahedron 2004, 60, 11139-11144.  Origins of “on-off” fluorescent behavior of 8-hydroxyquinoline-containing chemosensors.

 

73. Zhou, D.; Cantu, C. C.; Sagiv, Y.; Kulkarni, A. B.; Qi, X.; Morales, C.; Grabowski, G. A.; Benlagha, K.; Savage, P. B.; Bendelac, A. Teyton, L. Science 2004, 303, 523-527. Editing of Cd1-bound lipid antigens by endosomal lipid transfer proteins.

 

72. Xue, G.; Bradshaw, J. S.; Dalley, N. K.; Savage, P. B.; Izatt, R. M. J. Heterocyclic Chem. 2003, 40, 383-388. Synthesis of trans-disubstituted cyclam ligands appended with two 6-hydroxymethylpyridin-2-ylmethyl sidearms: crystal structures of the 1,8-dimethyl-4,11-di(6-hydroxymethylpyridin-2-ylmethyl)cylam ligand and its Co(II) and Ni(II) complexes.

 

71. Hook, G. L.; Kimm, G.; Betsinger, G.; Savage, P. B.; Swift, A.; Logan, T.; Smith, P. A. J. Sep. Sci. 2003, 26, 1091-1096. Solid phase microextraction sampling and gas chromatography/mass spectrometry for filed detection of the chemical warfare agent O-ethyl-S-(s-diisopropylaminoethyl)methylphosphonothiolate (VX).

 

70. Song, H.-C.; Chen. Y.W.; Yao, J.-H.; Bradshaw, J. S.; Savage, P. B.; Izatt, R. M. J. Heterocyclic Chem. 2003, 40, 475-479. Synthesis of diazadithiacrown ethers containing appended coumarin or 1-aminonaphthalene sidearms.

 

69. Hook, G. L.; Kimm, G.; Koch, D.; Savage, P. B.; Ding, B.; Smith, P. A. J. Chrom. A 2003, 992, 1-9. Detection of VX contamination in soil through solid-phase microextraction sampling and gas chromatography–mass spectrometry of the VX degradation product bis(diisopropylaminoethyl)disulfide.

 

68. Cantu, C.; Benlagha, K.; Savage, P. B.; Bendelac, A.; Teyton, L. J. Immunol. 2003, 170, 4673-4682. The paradox of immune molecular recognition of α-galactosylceramide: low affinity, low specificity for CD1d, high affinity for αβ T cell receptors.

 

67. Yin, N.; Marshall, R. L.; Matheson, S.; Savage, P. B. J. Am. Chem. Soc. 2003, 126, 2426-2435. Synthesis of lipid A derivatives and their interactions with polymyxin B and polymyxin B nonapeptide.

 

66. Kawakami, J.; Bronson, R. T.; Xue, G.; Bradshaw, J. S.; Izatt, R. M.; Savage, P. B. Supramol. Chem. 2003, 1, 221-227. Characterization of bis-8-hydroxyquinoline-armed diazatrithia-16-crown-5 and diazadibenzo-18-crown-6 ligands as fluorescent chemosensor for zinc.

 

65. Savage, P. B.; Li, C.; Taotafa, U.; Ding, B.; Guan, Q. FEMS Lett. 2002, 217, 1-7. Antibacterial properties of cationic steroid antibiotics.

 

64. Zhou, X. T.; Forestier, C.; Goff, R. D.; Li, C.; Teyton, L.; Bendelac, A.; Savage, P. B. Org. Lett. 2002, 4, 1267-1270. Synthesis and NKT cell stimulating properties of fluorophore and biotin appended 6”-amino-6”-deoxy-galactosylceramides.

 

63. Posner, R. G.; Savage, P. B.; Peters, A. S.; Macias, A.; DelGado, J.; Schwarz, G.; Sklar, L. A.; Hlavacek, W.; Goldstein, B. Molecular Immunol. 2002, 38, 1221-1228. A quantitative approach for studying IgE-FceRI aggregation.

 

62. Chiu, Y.-H.; Park, S.-H.; Benlagha, K.; Forestier, C.; Jayawardena-Wolf, J.; Savage, P. B.; Teyton, L.; Bendelac, A. Nature Immunol. 2002, 3, 55-60. Multiple defects of antigen presentation and T cell development in mice expressing tail-truncated CD1d.

 

61. Kluchinsky, T. A. Jr.; Savage, P. B.; Fitz, R.; Smith, P. A. AIHA Journal 2002, 63, 493-496. Liberation of hydrogen cyanide and hydrogen chloride during high temperature dispersion of CS riot control agent.

 

60. Ding, B.; Guan, Q.; Walsh, J. P.; Boswell, J. S.; Winter, T. W.; Winter, E. S.; Boyd, S. S.; Li, C.; Savage, P. B. J. Med. Chem. 2002, 45, 663-669. Correlation of the antibacterial activities of cationic peptide antibiotics and cationic steroid antibiotics.

 

59. Savage, P. B. Curr. Med. Chem. Anti-Infective Agents 2002, 3, 293-304. Cationic steroid antibiotics.

 

58. Savage, P. B. European J. Org. Chem. 2002, 759-768. Design, synthesis and characterization of cationic peptide and steroid antibiotics.

 

57. Xue, G.-P.; Bradshaw, J. S.; Dalley, N. K.; Savage, P. B.; Izatt, R. M.; Prodi, L.; Montalti, M.; Zaccheroni, N. Tetrahedron 2002, 58, 4809-4815. Synthesis of azacrown ethers with quinoline-based sidearms as potential zinc(II) fluorophores.

 

56. Song, H.-C.; Bradshaw, J. S.; Y.-W. Chen, Xue, G.-P.; Li, W.-M.; Krakowiak, K. E.; Savage, P. B.; Xu, Z.-L.; Izatt, R. M. Supramolecular Chem. 2002, 14, 263-269. Synthesis of new crown ethers containing appended pyridine, 10-hydroxybenzoquinoline, 8-hydroxyquinoline and 2-amino-1-hydroxybiphenyl sidearms.

 

55. Kluchinshy, T. A.; Sheely, M. V.; Savage, P. B.; Smith, P. A. J. Chromatography A 2002, 952, 205-213. Formation of 2-chlorobenzylidenemalononitrile (CS riot control agent) thermal degradation products at elevated temperatures.

 

54. Smith, P. A.; Kluchinsky, T. A.; Savage, P. B.; Erickson, R. P.; Lee, A. P.; Williams, K.; Stevens, M.; Thomas, R. J. AIHA J. 2002, 63, 284-292. Traditional sampling with laboratory analysis and solid phase microextraction sampling with field gas chromatography/mass spectrometry by military industrial hygienists.

 

53. Savage, P. B.; Li, C. “Steroid Derived Antibiotics,” US patent # 6,486,148, November 26, 2002.

 

52. Savage, P. B.; Li, C. “Steroid Derived Antibiotics,” US patent # 6,350,738, February 26, 2002.

 

51. Song, H. C.; Chen, Y.-W.; Song, J.-C.; Savage, P. B.; Xue, G.-P.; Chiara, J. A.; Krakowiak, K. E.; Izatt, R. M.; Bradshaw, J. S. J. Heterocyclic Chem. 2001, 38, 1369-1376. New diazadi(and tri)thia-21-crown-7 ethers containing 8-hydroxyquinoline side arms.

 

50. Xue, G.-P.; Bradshaw, J. S.; Dalley, N. K.; Savage, P. B.; Krakowiak, K. E.; Izatt, R. M.; Prodi, L.; Montalti, M.; Zaccheroni, N. Tetrahedron 200157, 7623-7628. Convenient synthesis and preliminary photophysical properties of novel 8-aminoquinoline appended diaza-18-crown-6 ligands.

 

49. Xue, G.-P.; Savage, P. B.; Krakowiak, K. E.; Izatt, R. M.; Bradshaw, J. S. J. Heterocyclic Chem. 2001, 38, 1453-1457. Synthesis of diazadibenzo-18-crown-6 ligands with appended chromophoric and fluorophoric groups as potential metal ion chemosensors.

 

48. Song, H. C.; Bradshaw, J. S.; Chen, Y.-W.; Xue, G.-P.; Chiara, J. A.; Krakowiak, K. E.; Savage, P. B.; Xue, Z.-L.; Izatt, R. M. ARKIVOK 2001, 2, ms#116. Syntheses of diazadithiacrown ethers containing two 8-hydroxyquinoline side arms.

 

47. Kluchinsky, T. A., Jr.; Savage, P. B.; Sheely, M. V.; Thomas R. J.; Smith, P. A. Microcolumn Sep. 2001, 13, 186-190. Identification of CS-derived compounds formed during heat-dispersion of CS riot control agent.

 

46. Bradshaw, J. S.: Song, H.-C.; Xue, G.-P.; Bronson, R. T.; Chiara, J. A.; Krakowiak, K. E.; Savage, P. B.; Izatt, R. M. Supramol. Chem. 2001, 13, 499-505. Synthesis of diazadi(and tri)thiacrown ethers containing two 5-substituent(or 2-methyl)-8-hydroxyquinoline side arms.

 

45. Savage, P. B. Annals of Med. 2001, 33, 167-171. Multidrug resistant bacteria: overcoming antibiotic permeability barriers of gram-negative bacteria.

 

44. Lee, S. C.; Izatt, R. M.; Zhang, X. X.; Nelsen, E. G.; Lamb, J. D.; Savage, P. B.; Bradshaw, J. S. Inorg. Chim. Acta 2001, 317, 174-180. Highly selective copper(II) ion receptors: tetraazacrown ethers bearing two 8-hydroxyquinoline side arms.

 

43. Bronson, R. T.; Bradshaw, J. S.; Savage, P. B.; Fuangwasdi, S.; Lee, S. C.; Krakowiak, K. E.; Izatt, R. M. J. Org. Chem. 2001, 66, 4752-4758. Bis-8-hydroxyquinoline-armed diazatrithia-15-crown-5 and diazathithia-16-crown-5 ligands: possible fluorophoric metal ion sensors.

 

42. Prodi, L.; Montalti, M.; Zaccheroni, N.; Bradshaw, J. S.; Izatt, R. M.; Savage, P. B. J. Incl. Phenom. 2001, 41, 123-127. pH dependence of the luminescent properties of metal ion complexes of 5-chloro-8-hydroxyquinoline appended diaza-18-crown-6.

 

41. Schmidt, E. J.; Boswell, S. R.; Walsh, J. P.; Schellenberg, M. M.; Winter, T. W.; Li, C.; Allman, G. W.; Savage, P. B. J. Antimicrob. Chemother. 2001, 47, 671-674. Activities of cholic acid-derived antimicrobial agents against multidrug-resistant bacteria.

 

40. Prodi, L.; Montalti, M; Zaccheroni, N; Bradshaw, J. S.; Izatt, R. M.; Savage, P. B. Tetrahedron Lett. 2001, 42, 2941-2944. Characterization of 5-methoxyquinoline appended diaza-18-crown-6 as a chemosensor for cadmium.

 

39.  Dalley, N. K.; Xue, G.-P.; Bradshaw, J. S.; Zhang, X. X.; Harrison, R. G.; Savage, P. B.; Krakowiak, K. E.; Izatt, R. M. J. Heterocyclic Chem. 2001, 38, 1-9. A new diaza-18-crown-6 ligand containing two quinolin-8-ylmethyl side arms: crystal structures and characterization of the ligand, the protonated ligand and its mononuclear barium (II) and dinuclear copper (II) complexes.

 

38. Xue, G.-P.; Bradshaw, J. S.; Song, H.-C.; Bronson, R. T.; Savage, P. B.; Krakowiak, K. E.; Izatt, R. M.; Prodi, L.; Montalti, M.; Zaccheroni, N. Tetrahedron 2001, 57, 87-91. A convenient synthesis and preliminary photophysical study of novel fluoroionophores: macrocyclic polyamines containing two dansylamidoethyl side arms.

 

37. Zhou, X.-T.; Rehman, A.; Li, C.; Savage, P. B. Org. Lett. 2000, 2, 3015-3018. Preparation of a protected triamino-analogue of cholic acid and sequential incorporation of amino acids in solution and on a solid support.

 

36. Taotafa, U.; McMullin, D. M.; Lee, S. C.; Savage, P. B. Org. Lett. 2000, 2, 4117-4120. Anionic facial amphiphiles from cholic acid.

 

35. Guan, Q.; Schmidt, E. J.; Boswell, S. R.; Li, C.; Allman, G. W.; Savage, P. B. Org. Lett. 2000, 2, 2837-2840. Preparation and characterization of cholic acid-derived antimicrobial agents with controlled stabilities.

 

34. Prodi, L.; Bargossi, C.; Montalti, M.; Zaccheroni, N.; Su, N.; Bradshaw, J. S.; Izatt, R. M.; Savage, P. B. J. Am. Chem. Soc. 2000, 122, 6769-6770. An effective fluorescent chemosensor for mercury ions.

 

33. Savage, P. B.; Li, C. Exp. Op. Invest. Drugs 2000, 9, 263-269. Cholic acid derivatives: novel antimicrobials.

 

32. Xue, G.-P.; Bradshaw, J. S.; Su, N.; Krakowiak, K. E.; Savage, P. B.; Izatt, R. M. J. Heterocyclic Chem. 2000, 37, 1-9. Syntheses of two 1,3-2,4-calix[4]bis-crown ethers containing two 1,2-phenylene and one pyridine or anisole units in each crown ether moiety.

 

31. Su, N.; Bradshaw, J. S.; Xue, G.; Dalley, N. K.; Zhang, X. X.; Savage, P. B.; Krakowiak, K. E.; Izatt, R. M. J. Heterocyclic Chem. 2000, 37, 711-720. Synthesis, crystal structures, and metal ion complexation studies of novel diaza-18-crown-6 ligands containing aromatic thiol-derived side arms.

 

30. Fleming, S. A.; Hart, G. R.; Savage, P. B. J. Chem. Ed. 2000, 77, 790-794. Molecular orbital animations for organic chemistry.

 

29. Xue, G.-P.; Bradshaw, J. S.; Chiara, J. A.; Savage, P. B.; Krakowiak, K. E.; Izatt, R. M. Syn. Lett. 2000, 1181-1183. “A convenient synthesis of novel fluorophores: macrocyclic polyamines containing two dansylamidoethyl side arms.

 

28.  Xue, G.-P.; Savage, P. B.; Bradshaw, J. S.; Zhang, X. X.; Izatt, R. M. in Advances in Supramolecular Chemistry, Vol. 7; JAI Press, 2000, pp. 99-137. Functionalized macrocyclic ligands as sensory molecules for metal ions.

 

27. Bradshaw, J. S.; Izatt, R. M.; Savage, P. B.; Bruening, R. L.; Krakowiak, K. E. Supramolecular Chem. 2000, 12, 23-38. The design of ion selective macrocycles and the solid-phase extraction of ions using molecular recognition technology: A synopsis.

 

26. Li, C.; Lewis, M. R.; Gilbert, A. B.; Noel, M. D.; Scoville, D. H.; Allman, G. W.; Savage, P. B. Antimicrob. Agents. Chemother. 1999, 43, 1347-1351. Antimicrobial activities of amine- and guanidine-functionalized cholic acid derivatives.

 

25. Li, C.; Budge, L. P.; Driscoll, C. D.; Willardson, B. M.; Allman, G. W.; Savage, P. B. J. Am. Chem. Soc. 1999, 121, 931-940. Incremental conversion of outer-membrane permeabilizers into potent antibiotics for Gram-negative bacteria.

 

24. Rehman, A.; Li, C.; Budge, L. P.; Street, S. E.; Savage, P. B. Tetrahedron Lett. 1999, 40, 1865-1868. Preparation of amino acid-appended cholic acid derivatives as sensitizers of Gram-negative bacteria.

 

23. Li, C.; Rehman, A.; Dalley, N. K.; Savage, P. B. Tetrahedron Lett. 1999, 40, 1861-1864. Short syntheses of triamine-derivatives of cholic acid.

 

22. Su, N.; Bradshaw, J. S.; Zhang, X. X.; Song, H.-C.; Savage, P. B.; Xue, G.-P.; Krakowiak, K. E.; Izatt, R. M. J. Org. Chem. 1999, 64, 8855-8865. Syntheses and metal ion complexation of novel 8-hydroxyquinoline-containing diaza-18-crown-6 ligands and analogs.

 

21. Su, N.; Bradshaw, J. S.; Savage, P. B.; Krakowiak, K. E.; Izatt, R. M.; DeWall, S. L.; Gokel G. W. Tetrahedron 1999, 55, 9737-9746. Syntheses and aggregate study of bisphenol-containing diaza-18-crown-6 ligands.

 

20. Su, N.; Bradshaw, J. S.; Savage, P. B.; Krakowiak, K. E.; Izatt, R. M. J. Org. Chem. 1999, 64, 3825-3836. Diaza-18-crown-6 ligands containing two aminophenol sidearms: new heterobinuclear metal ion receptors.

 

19. Yang, Z.; Bradshaw, J. S.; Zhang, X. X.; Savage, P. B.; Krakowiak, K. E.; Dalley, N. K.; Su, N.; Bronson, T.; Izatt, R. M. J. Org. Chem. 1999, 64, 3162-3172. New tetraazacrown ethers containing two pyridine, quinoline, 8-hydroxyquinoline or 8-aminoquinoline sidearms.

 

18. Su, N.; Bradshaw, J. S.; Savage, P. B.; Krakowiak, K. E.; Izatt, R. M. J. Heterocyclic Chem. 1999, 36, 771-780. Syntheses of diaza-18-crown-6 ligands containing two 4-hydroxyazobenzene, two benzimidazole, two uracil, two anthraquinone, or two ferrocene units.

 

17.    Fleming S. A.; Hart, G. R.; Savage, P. B. Organic Reaction Animations v1.5; W. W. Norton: New York, 1999. (Fleming S. A.; Hart, G. R.; Savage, P. B. Organic Reaction Animations v1.0; W. W. Norton: New York, 1998.)

 

16. Li, C.; Peters, A. S.; Meredith, E. L.; Allman, G. H.; Savage, P. B. J. Am. Chem. Soc. 1998, 120, 2961-2962. Design and synthesis of potent sensitizers of Gram-negative bacteria based on a cholic acid scaffolding.

 

15. Prodi, L.; Bolletta, F.; Montalti, M.; Zaccheroni, N.; Savage, P. B.; Bradshaw, J. S.; Izatt, R. M. Tetrahedron Lett. 1998, 39, 5451-5454. A fluorescent sensor for magnesium ions.

 

14. Marshall, R. L.; Dalley, N. K.; Savage, P. B. Tetrahedron Lett. 1998, 39, 3923-3926. Synthesis of novel 3’,6’-dideoxy-3’,6’-epithio and 2’,6’-dideoxy-2’,6’-epithio nucleosides.

 

13. Smith, P. A.; Bowerbank, C. R.; Savage, P. B.; Drown, D. B.; Lee, M. L.; Alexander, W.; Jederberg, W. W.; Still, K. Appl. Occ. Env. Hygiene 1998, 14, 171-179. Conjugation of 7-oxodehydroabietic acid to lysine, a haptenation mechanism for an oxidized resin acid with dermal sensitizing properties.

 

12. Bordunov, A. V.; Bradshaw, J. S.; Bastushok, V. N.; Zhang, X. X.; Kou, X.; Dalley, N. K.; Yang, Z.; Savage, P. B.; Izatt, R. M. Tetrahedron 1997, 53, 17595-17603. Azacrown ethers containing oximic and Schiff base sidearms-potential heteronuclear metal ion receptors.

 

11. Savage, P. B.; Thomas, W. D.; Dalley, N. K. J. Incl. Phenom. 1997, 29, 335-339. Synthesis of two new glycophanes comprised of thioglucose molecules linked by hydrocarbons.

 

10. Homlgren, S. K.; Savage, P. B.; Desper, J. M.; Schladetzky, K. D.; Powell, D. R.; Gellman, S. H. Tetrahedron, 1997, 53, 12249-12257. Steric control of oxidation selectivity in macrocyclic phosphine oxide-dithioethers

 

9. Paquette, L. A.; Sun, L.-Q.; Friedrich, D.; Savage, P. B. J. Am. Chem. Soc. 1997, 119, 8438-8439. Total synthesis of (+)-epoxydictymene.  Application of alkoxy-directed cyclization to diterpenoid construction.

 

8. Paquette, L. A.; Sun, L.-Q.; Friedrich, D.; Savage, P. B. Tetrahedron Lett. 1997, 38, 195-199. Highly enantioselective total synthesis of natural epoxydictymene.  An alkoxy-directed cyclization route to highly strained trans-oxabicyclo[3.3.0]octanes.

 

7. Savage, P. B.; Holmgren, S. K.; Gellman, S. H. J. Am. Chem. Soc. 1994, 116, 4069-4070. Anion and ion pair complexation by a macrocyclic phosphine oxide disulfoxide.

 

6. Savage, P. B.; Gellman, S. H. J. Am. Chem. Soc. 1993, 115, 10448-10449. Complexation of ammonium hexoses:  evidence for contributions from OH-OH hydrogen bonds in a hydroxylic medium.

 

5. Savage, P. B.; Holmgren, S. K.; Gellman, S. H. J. Am. Chem Soc. 1993, 115, 7900-7901. Optimization of a phosphine oxide-disulfoxide array for multipoint hydrogen bonding to ammonium ions.

 

4. Savage, P. B.; Holmgren, S. K.; Desper, J. M.; Gellman, S. H. Pure Appl. Chem. 1993, 65, 461-468. Macrocycles containing sulfur and phosphorus:  structure and complexation properties.

 

3. Savage, P. B.; Desper, J. M.; Gellman, S. H. Tetrahedron Lett. 1992, 33, 2107-2110. Stereoselective oxidation of an eleven-membered heterocycle.

 

2. McDaniel, C. W.; Bradshaw, J. S.; Krakowiak, K. E.; Izatt, R. M.; Savage, P. B.; Tarbet, B. J.; Bruening, R. L. J. Heterocyclic Chem. 1989, 26, 413-419. Preparation of crown compounds containing allyloxymethyl or butenyl groups for attachment to silica gel or containing long chain lipophilic groups for use in liquid membrane systems.

 

1. Bradshaw, J. S.; Krakowiak, K. E.; Bruening, R. L.; Tarbet, B. J.; Savage, P. B.; Izatt, R. M. J. Org. Chem. 1988, 53, 3190-3197. Synthesis of (allyloxy)methyl-substituted diaza-18-crown-6 compounds for attachment to silica gel.