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Publications

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Publications by Morris J. Robins.

  1. Z. Janeba, X. Lin, and M. J. Robins "Functionalization of Guanosine and 2'-Deoxyguanosine at C6: A Modified Appel Process and SNAr Displacement of Imidazole" Nucleosides Nucleotides Nucleic Acids, 23, 137-147 (2004).

  2. M. F. Vickers, J. Zhang, F. Visser, T. Tackaberry, M. J. Robins, L. P. C. Nielsen, I. Nowak, S. A. Baldwin, J. D. Young, and C. E. Cass "Uridine Recognition Motifs of Human Equilibrative Nucleoside Transporters 1 and 2 Produced in Saccharomyces cerevisiae" Nucleosides Nucleotides Nucleic Acids, 23, 361-373 (2004).

  3. P. Francom and M. J. Robins "Nucleic Acid Related Compounds. 118. Nonaqueous Diazotization of Aminopurine Derivatives. Convenient Access to 6-Halo- and 2,6-Dihalopurine Nucleosides and 2'-Deoxynucleosides with Acyl or Silyl Halides " J. Org. Chem., 68, 666-669 (2003).

  4. Z. Janeba, P. Francom, and M. J. Robins "Efficient Syntheses of 2-Chloro-2'-deoxyadenosine (Cladribine) from 2'-Deoxyguanosine" J. Org. Chem., 68, 989-992 (2003).

  5. I. Nowak and M. J. Robins "Protection of the Amino Group of Adenosine and Guanosine Derivatives by Elaboration into a 2,5-Dimethylpyrrole Moiety" Org. Lett., 5, 3345-3348 (2003).

  6. M. J. Robins "Ribonucleotide Reductases: Radical Chemistry and Inhibition at the Active Site" Nucleosides Nucleotides Nucleic Acids , 22, 519-534 (2003).

  7. M. Zhong and M. J. Robins "Regioisomers in Vorbrüggen's Guanine Nucleoside Synthesis; N9 Selectivity with a Glucosamine Derivative and 2-N-Acetyl-6-O-diphenylcarbamoylguanine" Tetrahedron Lett., 44, 9327-9330 (2003).

  8. J. Zhang, F. Visser, M. F. Vickers, T. Lang, M. J. Robins, L. P. C. Nielsen, I. Nowak, S. A. Baldwin, J. D. Young, and C. E. Cass "Uridine Binding Motifs of Human Concentrative Nucleoside Transporters 1 and 3 Produced in Saccharomyces cerevisiae " Mol. Pharmacol., 64, 1512-1520 (2003).

  9. S. F. Wnuk, S. M. Chowdhury, P. I. Garcia, Jr., and M. J. Robins "Stereodefined Synthesis of O3'-Labeled Uracil Nucleosides. 3'-[17O]-2'-Azido-2'-deoxyuridine 5'-Diphosphate as a Probe for the Mechanism of Inactivation of Ribonucleotide Reductases " J. Org. Chem., 67, 1816-1819 (2002).

  10. P. Francom, Z. Janeba, S. Shibuya, and M. J. Robins "Nucleic Acid Related Compounds. 116. Nonaqueous Diazotization of Aminopurine Nucleosides. Mechanistic Considerations and Efficient Procedures with tert-Butyl Nitrite or Sodium Nitrite " J. Org. Chem., 67, 6788-6796 (2002).

  11. R. W. Miles, L. P. C. Nielsen, G. J. Ewing, D. Yin, R. T. Borchardt, and M. J. Robins "S-Homoadenosyl-L-cysteine and S-Homoadenosyl-L-homocysteine. Synthesis and Binding Studies of Non-Hydrolyzed Substrate Analogues with S-Adenosyl-L-homocysteine Hydrolase" J. Org. Chem., 67, 8258-8260 (2002).

  12. S. F. Wnuk, D. R. Companioni, V. Neschadimenko, and M. J. Robins "The b-Fluorine Effect. Electronic Versus Steric Effects in Radical Deoxygenations of Fluorine-Containing Pentofuranose Nucleosides" J. Org. Chem., 67, 8794-8797 (2002).

  13. M. J. Robins, J. S. Wilson, D. Madej, D. L. J. Tyrrell, W. P. Gati, R. J. Lindmark, and S. F. Wnuk "Nucleic Acid Related Compounds. 114. Synthesis of 2,6-(Disubstituted)purine 2',3'-Dideoxynucleosides and Selected Cytotoxic, Anti-Hepatitis B, and Adenosine Deaminase Substrate Activities" J. Heterocycl. Chem. , 38, 1297-1306 (2001).

  14. M. J. Robins, R. W. Miles, M. C. Samano, and R. L. Kaspar "Syntheses of Puromycin from Adenosine and 7-Deazapuromycin from Tubercidin, and Biological Comparisons of the 7-Aza/Deaza Pair" J. Org. Chem., 66, 8204-8210 (2001).

  15. M. J. Robins, B. Doboszewski, V. A. Timoshchuk, and M. A. Peterson "Glucose-Derived 3'-(Carboxymethyl)-3'-deoxyribonucleosides and 2',3'-Lactones as Synthetic Precursors for Amide-Linked Oligonucleotide Analogues" J. Org. Chem., 65, 2939-2945 (2000).

  16. M. J. Robins, B. Doboszewski, B. L. Nilsson, and M. A. Peterson "Synthesis of Amide-Linked [(3')CH2CO–NH(5')] Nucleoside Analogues of Small Oligonucleotides " Nucleosides Nucleotides, 19, 69-86 (2000).

  17. S. F. Wnuk, C. A. Valdez, J. Khan, P. Moutinho, M. J. Robins, X. Yang, R. T. Borchardt, J. Balzarini, and E. De Clercq "Doubly Homologated Dihalovinyl and Acetylene Analogues of Adenosine: Synthesis, Interaction with S-Adenosyl-L-homocysteine Hydrolase, and Antiviral and Cytostatic Effects " J. Med. Chem., 43, 1180-1186 (2000).

  18. X. Lin and M. J. Robins "Mild and Efficient Functionalization at C6 of Purine 2'-Deoxynucleosides and Ribonucleosides" Org. Lett., 2, 3497-3499 (2000).

  19. E. S. Kumarasinghe, M. A. Peterson, and M. J. Robins "Synthesis of 5,6-Bis(alkyn-1-yl)pyrimidines and Related Nucleosides" Tetrahedron Lett., 41, 8741-8745 (2000).

  20. X. Yang, D. Yin, S. F. Wnuk, M. J. Robins, and R. T. Borchardt "Mechanisms of Inactivation of Human S-Adenosylhomocysteine Hydrolase by 5',5',6',6'-Tetradehydro-6'-deoxy-6'-halohomoadenosines" Biochemistry, 39, 15234-15241 (2000).

  21. S.F. Wnuk and M.J. Robins, "Stannyl Radical-Mediated Cleavage of p-Deficient Heterocyclic Sulfones. Synthesis of a-Fluoro Esters and the First Homonucleoside a-Fluoromethylene Phosphonate," J. Am. Chem. Soc., 118, 2519-2520 (1996).
  22. R.W. Miles, V. Samano, and M.J. Robins, "Nucleic Acid Related Compounds. 86. Nucleophilic Functionalization of Adenine, Adenosine, Tubercidin, and Formycin Derivatives via Elaboration of the Heterocyclic Amino Group into a Readily Displaced 1,2,4-Triazol-4-yl Substituent," J. Am. Chem. Soc., 117, 5951-5957 (1995).

  23. M.J. Robins, M.C. Samano, and V. Samano, "Ribonucleotide Reductase Targets for Chemotherapy; Mechanistic Aspects and Biologically Active Agents," Nucleosides Nucleotides, 14, 485-493 (1995).

  24. M.J. Robins, J.S. Wilson, D. Madej, N.H. Low, F. Hansske, and S.F. Wnuk, "Nucleic Acid Related Compounds. 88. Efficient Conversions of Ribonucleosides into Their 2',3'-Anhydro, 2'(and 3')-Deoxy, 2',3'-Didehydro-2',3'-dideoxy, and 2',3'-Dideoxynucleoside Analogues," J. Org. Chem., 60, 7902-7908 (1995).

  25. M.J. Robins, S.F. Wnuk, K.B. Mullah, N.K. Dalley, C.-S. Yuan, Y. Lee, and R.T. Borchardt, "Nucleic Acid Related Compounds. 80. Synthesis of 5'-S-(Alkyl and aryl)-5'-fluoro-5'-thioadenosines with Xenon Difluoride or (Diethylamido)sulfur Trifluoride, Hydrolysis in Aqueous Buffer, and Inhibition of S-Adenosyl-L-homocysteine Hydrolase by Derived Adenosine 5'-Aldehyde Species," J. Org. Chem., 59, 544-555 (1994).

  26. A.H. Cory, V. Samano, M.J. Robins, and J.G. Cory, "2'-Deoxy-2'-methylene Derivatives of Adenosine, Guanosine, Tubercidin, Cytidine, and Uridine as Inhibitors of L1210 Cell Growth in Culture," Biochem. Pharmacol., 47, 365-371 (1994).

  27. V. Samano and M.J. Robins, "Synthesis of 3'-Deoxyadenosine-3'-spirocyclopropane, 3'-Deoxyuridine-3'-spirocyclopropane, and 5'-Deoxy-4',5'-methanoadenosine," Tetrahedron Lett., 35, 3445-3448 (1994).

  28. S.F. Wnuk, C.-S. Yuan, R.T. Borchardt, J. Balzarini, E. De Clercq, and M.J. Robins, "Nucleic Acid Related Compounds. 84. Synthesis of 6'(E and Z)-Halohomovinyl Derivatives of Adenosine, Inactivation of S-Adenosyl-L-homocysteine Hydrolase, and Correlation of Anticancer and Antiviral Potencies with Enzyme Inhibition," J. Med. Chem., 37, 3579-3587 (1994).

  29. C.-S. Yuan, S.F. Wnuk, S. Liu, M.J. Robins, and R.T. Borchardt, "(E)-5',6'-Didehydro-6'-deoxy-6'-fluorohomoadenosine: A Stubstrate That Measures the Hydrolytic Activity of S-Adenosylhomocysteine Hydrolase," Biochemistry, 33, 12305-12311 (1994).

  30. M.J. Robins and S.F. Wnuk, "Selected Aspects of the Chemistry and Biochemistry of Sulfur-Containing Nucleosides," Phosphorus Sulfur, 95-96, 71-88 (1994).

  31. S. Salowe, J.M. Bollinger, Jr., M. Ator, J. Stubbe, J. McCracken, J. Peisach, M.C. Samano, and M.J. Robins, "Alternative Model for Mechanism-Based Inhibition of Escherichia coli Ribonucleotide Reductase by 2'-Azido-2'-deoxyuridine 5'-diphosphate," Biochemistry, 32, 12749-12760 (1993).

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