Forgot your password?
Research Interests
—
filed under:
daniel simmons research interests
Research Interests by Daniel L. Simmons.
|
My laboratory's research focuses on signal transduction in the cancer
cell. In particular, we are interested in a group of genes we have
cloned that are activated during cell division. Our research determined
that one of these genes encodes a previously undescribed
cyclooxygenase, a critical enzyme involved in the synthesis of
prostaglandins and thromboxane. These fatty-acid derived molecules are
hormone-like messengers that play a role in many critical physiological
processes, including inflammation. Aspirin and other antiinflammatory
drugs inhibit cyclooxygenase, and reduce fever, pain, and inflammation
through inhibiting this enzyme. We continue to investigate the role(s)
of cyclooxygenase in cancer formation. Additionally we work on other
growth-associated genes, including oncogenes and anti-oncogenes, that
may provide insight into solving the mystery of cancer.
 |
